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KMID : 0363620130340020029
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Journal of Korean Oriental Medicine
2013 Volume.34 No. 2 p.29 ~ p.40
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Literature Review on Biological Effects of Gyejibokryeong-hwan against Gynaecological Diseases
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Kim Jung-Hoon
Shin Hyeun-Kyoo
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Abstract
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Objectives: To investigate therapeutic mechanisms of Gyejibokryeong-hwan (GJBRH) against gynaecological diseases, articles on biological assay were gathered and analyzed.
Methods: The articles were classified as being from domestic or international journals, and by their year of publication. The mechanisms of the biological effects against gynaecological diseases were noted.
Results: Of the 14 articles analyzed, 13 were published in China and 1 was from Japan. GJBRH showed therapeutic effect against uterine and mammary gland diseases. Uterine-related diseases such as endometriosis, hysteromyoma, adenomyosis, cancer, and inflammation can be improved by the administration of GJBRH through anti-angiogenesis, anti-inflammation, the modulation of immune cell and immunoglobulin, and the regulation of hormone secretion. GJBRH also reduced mammary hyperplasia by regulating hormone and cytokine release.
Conclusions: We speculate that the inhibitory effect against uterine and mammary gland diseases could be related to the therapeutic efficacy of GJBRH in improving gynaecological diseases.
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KEYWORD
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Gyejibokryeong-hwan, gynaecological disease, therapeutic mechanism, uterine, mammary gland
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